A Possible Inhibitory Effect of Physalis (Physalis pubescens L.) On Diabetes in Male Rats

The present study was designed to investigate the possible antidiabetic, hypolipidaemic and antioxidant effects of physalis. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150 mg/kg, body weight i.p). Physalis was administered at a single 1 ml dose per day to these diabetic rats for 21 days. The effect of physalis on blood glucose, serum insulin and pancreatic insulin, serum troponin, tumor necrosis factor (TNF ), interleukin 6 (IL6), vascular endothelial growth factor (VEGF), serotonin, dopamine and malondialdyhyde (MDA) were measured in the diabetic rats. Moreover, on the last day the pancreas were removed and stained with hematoxylin and eosin (H & E) and morphology of the pancreatic sections was studied. Besides, immunohistochemical, insulin and Bcl of pancreas. The results of this study indicate that 2 physalis elicited significant (p<0.05) reductions of blood glucose, troponin, TNF and IL6 except VEGF, dopamine and serotonin were significantly increased. Physalis also caused significant increase in serum insulin (p<0.05) in the diabetic rats. The results suggest physalis could be considered as a potential candidate for developing a new anti-diabetic agent. Through, offers promising antidiabetic effects that may be mainly attributed to its potent antioxidant potential. As well as the important factor of this agent in the resistance of beta cells of the pancreas and insulin-producing for the free radicals caused by diabetes. This is the first study on the possibility of Physalis pubescens juice as an inhibitory effect on diabetes in rats through its possibility impact of anti-free radicals in the beta cells of the pancreas.